It is a huge day for both clubs with Spurs and the Magpies having their eyes on a top-four finish come the end of the campaign.
Both teams were on the losing side last weekend, with Tottenham failing to capitalise on Newcastle's 3-0 defeat at Aston Villa as they slumped to a surprise 3-2 home loss against lowly Bournemouth.
That means Eddie Howe's team go into today's game in fourth with a three-point advantage over the Lilywhites.
With the focus very much still on Champions League football despite their mixed form, this is the first of three huge games for Tottenham in a pivotal week as Manchester United and Liverpool are on the agenda in the days ahead.
Tottenham correspondents Alasdair Gold and Rob Guest are covering the match with all the build-up and the action as it happens on the pitch and reaction from the supporters and media.
Atrocious Spurs concede five goals in 21 minutes
This was to be the start of a defining week for Tottenham. The first 20 minutes at St. James' Park told the world more than enough. This is a team devoid of organization, character and quality. The matches against Manchester United and Liverpool that follow this calamitous display will not offer any hope of an unlikely top-four finish. Instead, Spurs look ready to tumble further down the league, out of the European places and into midtable.
Even that would be a generous reflection of their performance in this 6-1 defeat at Newcastle, a team who have streaked ahead of them in no time. Before kickoff, this was fourth against fifth, a playoff for Champions League riches in theory. In practice, it felt rather more significant even than that. This may yet go down as a landmark moment for the victors, a day where they firmly established themselves among the Premier League's top four. With Saudi riches backing them, they are well placed to entrench that position.
This may well be the dying day of a Tottenham dynasty that has been slowly disassembling since losing the Champions League final in 2019. As Mauricio Pochettino's great side aged out or moved on to pastures new, their presence in Europe's big leagues became more fleeting but they tended to be in the mix for a top-four finish at least. Now, with five tricky games left to play, it seems eminently plausible that they could be lapped by Aston Villa, Liverpool, Brighton and perhaps even Fulham. Only once in the last 16 seasons have Tottenham missed out on European football and the riches that come with it entirely. That may be about to change. How could a team who delivered a performance as wretched as this represent the Premier League on the continental stage?